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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2000 Vol.8 No.4 P.199-201
外耳道间断加压对豚鼠耳蜗外侧壁心钠素表达的影响
Effects of Intermittent Overpressure in Ear Canal on Expression of ANP in Cochlear Lateral Wall of Guinea Pigs
徐志勇
刘兆华
摘 要：目的研究外耳道49和20cmH2O间断加压对豚鼠听功能及耳蜗外侧壁心钠素(ANP)表达的影响。方法建立豚鼠外耳道间断加压模型，观察49和20cmH2O压力引起的中、内耳病理改变及AEP阈值改变，用免疫组化SP法研究心钠素在耳蜗外侧壁的表达。结果49cmH2O间断加压引起鼓膜松驰部和中耳粘膜出血，各频率反应阈平均提高12.09dB；20cmH2O间断加压对中耳及内耳均无明显损伤，不影响AEP阈值；间断加压使ANP在耳蜗外侧壁表达减弱。结论20cmH2O的压力相对安全，可以此为参考进行外耳道加压实验。耳蜗外侧壁ANP阳性细胞可能有内分泌或旁分泌的作用。
关键词：压力；外耳道；心钠素；听觉诱发电位
文章编号：1006-7299(2000)04-0199-03
作者简介：徐志勇(1966-)，男，河北人，主治医师，硕士，主要从事耳科学及耳神经外科学研究。
作者单位：徐志勇（解放军第251医院耳鼻咽喉科河北张家口 075000）
刘兆华（第三军医大学附属大坪医院耳鼻咽喉-头颈外科）
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