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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2003 Vol.11 No.1 P.69-70
毛细胞离子通道与音位分布的关系
郭英
苏振伦
文章编号：1006-7299(2003)01-0069-02
毛细胞进行机械-电换能活动的离子基础如下:当静纤毛受到刺激,纤毛的顶连接(tip-link)受到牵拉[1],从而改变纤色顶端机械门控离子通道的电导,K+通过其顶部的换能通道流人细胞,使细胞去极化,又使电压依赖性钙通道激活,Ca2+流人细胞,又激活了侧膜上的钙激活钾(Ca2+-actiratedK+,Ka)通道,K+流出细胞,使膜复极化,钙(Ca)通道失活,Ca2+泵活动,恢复胞内外Ca2+的梯度,由此构成振荡性膜电位.在毛细胞产生感受器电位时,毛细胞底部突触前膜向突触间隙释放化学递质,并使突触后膜去极化,产生突触后电位.当电位达到一定程度则引起听神经纤维终末的扩布性兴奋,产生动作电位. ……
基金项目：国家自然科学基金资助项目(编号39970787)
作者单位：郭英（中国人民解放军263医院耳鼻咽喉科,北京,101149）
苏振伦（解放军总医院耳鼻咽喉科研究所）
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