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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2002 Vol.10 No.2 P.84-86
突发性聋患者血浆一氧化氮、脂质过氧化酶、丙二醛水平的测定
Levels of NO、SOD、GSH-Px and MDA in Patients with Sudden Deafness
王鹏举
王锦云
李仁济
余晔
李琦
摘 要：目的探讨突发性聋患者体内一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平的变化及其临床意义.方法测定30例突发性聋患者和20例正常健康人血浆NO、SOD、GSH-Px、MDA的浓度.结果与正常对照组相比,突发性聋患者血浆NO、SOD、GSH-Px浓度显著低于正常对照组,而MDA水平显著高于正常对照组(P＜0.01);不同程度耳聋组之间NO、GHS-Px无显著性差异,而在SOD、MDA之间的差异有显著性.治疗后血浆NO、SOD、GSH-Px的活性明显升高.MDA水平明显降低,与治疗前相比有显著性差异.结论突发性聋患者体内NO、SOD、GSH-Px含量下降,而MDA水平增高,建议治疗该病可应用NO合成诱导剂和外源性SOD或其他抗氧化剂,以提高突发性聋的治疗效果.
关键词：突发性聋 一氧化氮 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛
文章编号：1006-7299(2002)02-0084-03
作者简介：王鹏举(1966-),男,湖北人,副主任医师,硕士,主要从事耳鼻咽喉科临床工作
作者单位：王鹏举（湖北省襄樊市中心医院耳鼻咽喉科,襄樊,441021）
王锦云（湖北省襄樊市中心医院耳鼻咽喉科,襄樊,441021）
李仁济（湖北省襄樊市中心医院耳鼻咽喉科,襄樊,441021）
余晔（湖北省襄樊市中心医院耳鼻咽喉科,襄樊,441021）
李琦（湖北省襄樊市中心医院耳鼻咽喉科,襄樊,441021）
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