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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2002 Vol.10 No.2 P.125-126
跨屏障内耳局部给药研究进展
罗伟
孙建军
文章编号：1006-7299(2002)02-0125-02
1 内耳的结构特点及其局部给药的解剖基础由于血迷路屏障的存在,与其他器官相比,内耳与身体其他部分是相对独立的.圆窗膜的半渗透性使得某些药物通过圆窗直接渗透进入鼓阶外淋巴液.耳蜗的骨质结构既可为局部给药和固定提供条件,又可防止药物向周围组织器官扩散,而内耳淋巴液的流动性能使药物很快均匀分布,不会在注射部位蓄集.从某种意义上说,内耳局部给药的实质是一种跨血-迷路屏障的治疗模式,对某些不能通过血脑屏障、系统使用毒性大、半衰期短的药物,跨屏障局部用药具有显著的优越性.……
作者单位：罗伟（海军总医院全军耳鼻咽喉科中心,北京,100037）
孙建军（海军总医院全军耳鼻咽喉科中心,北京,100037）
参考文献：
［1］Nedzelski J,Chiong C,Fradel G,et al.Intratympanic gentamicin installation as treatment of unilatent Meniere's disease:update of an ongoing study [J]. Acta Otolaryngol(Stockh),1998,118:294.
［2］McFeely WJ, Singleton GT, Rodriguez FJ,et al.Intratympanic genta micin treatment for Meniere's disease [J]. Otolaryngol Head Neck Surg.1998,118:589.
［3］Silverstein H.Use of a new device,the MicroWick,to deliver medication to the inner ear [J].Ear Nose Throat J,1999,78:595.
［4］Charabi S,Thomsen J,Tos M.Round window gentamicin u-caheter-a new therapeutic tool in Meniere's disease [J]. Acta Otolaryngol,2000,(suppl)543:108.
［5］Yagi M,Magal E,Sheng Z,et al.Hair cell protection from aminoglycoside ototoxity by adenovirus-mediated overexpression of glial cell line-derived neurotrophic factor [J]. Hum Gene Ther,1999,10:813.
［6］郭维,胡吟燕,翟所强.腺病毒携带的LacZ在豚鼠耳蜗中的表达[J].听力学及言语疾病杂志,2001,9:36.
［7］Staecker H,Gabaizadeh R,Federoff H,et al.Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss [J]. Otolaryngol Head Nech Surg,1998,119:7.
［8］Brown JN,Miller JM,Altschuler RA,et al.Osmotic pump implants for chronic infusions of drugs into the inner ear [J].Hear Res,1993,70:167.
［9］Lalwani AK,Walsh BJ,Reilly PG,et al.Development of in vivo gene therapy for hearing disorders:introduction of adeno-associated virus into the guinea pig[J].Gene ther,1996,3:588.
［10］Ylikoski J,Pirvola U,Virkkala J,et al.Guinea pig auditory neurons are protected by glial cell line-derived growth factor from degeneration after noise trauma[J]. Hear Res,1998,124:17.
［11］Shoji F,Yamasoba T,Magal E,et al.Glial cell line-derived neurotrophic factor has a dose dependent influence on noise-induced hearing loss in the guinea pig cochlear[J].Hear Res,2000,142(1-2):41.
［12］Yamasoba T,Schacht J,Shoji F,et al.Attenuation of cochlear damage from noise trauma by an iron chelator,a free radical scavenger and glial cell line-derived neurotrophic factor in vivo[J].Brain Res,1999,815:317.