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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2002 Vol.10 No.2 P.102-103
小白鼠实验性分泌性中耳炎粘附分子的表达
Expression of Cell Adhesion Melecules in Experimented Otitis Media with Effusion in Rats
王胜资
王纾宜
严月华
梁琴
摘 要：目的研究粘附分子表达与分泌性中耳炎的关系.方法采用灭活未分类流感嗜血杆菌制备小白鼠分泌性中耳炎模型,了解中耳粘膜的病理改变,检测其对白细胞粘附分子表达的影响.结果实验组小白鼠粘附分子Mac-1和L-selectin的表达明显增加,伴有相应中耳粘膜病理改变.结论死亡的细菌可能作为一种抗原,导致中耳粘膜的炎症反应及中耳渗出,粘附分子Mac-1及L-selectin的表达与炎症反应密切相关.
关键词：小白鼠 分泌性中耳炎 粘附分子
文章编号：1006-7299(2002)02-0102-02
作者简介：王胜资(1960-),女,浙江人,博士,主任医师,主要从事头颈部肿痛放射并发症研究
作者单位：王胜资（复旦大学附属眼耳鼻喉科医院放疗科,上海,200031）
王纾宜（复旦大学附属眼耳鼻喉科医院病理科,上海,200031）
严月华（复旦大学附属眼耳鼻喉科医院耳鼻咽喉科,上海,200031）
梁琴（复旦大学附属眼耳鼻喉科医院耳鼻咽喉科,上海,200031）
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