听力学及言语疾病杂志文献:颈上神经节切除对豚鼠内淋巴囊血流量影响机制的研究

本站文献皆为网友上传共享免费提供给大家,如有侵权,请告知我们尽快删除!
后下载此文档!
听力学及言语疾病杂志
JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2002 Vol.10 No.4 P.262-263,275
颈上神经节切除对豚鼠内淋巴囊血流量影响机制的研究
The Effoct of Superior Cervical Ganglion Resection on the Endoly mphatic Sac Blood Flow
窦艳玲 
冯怀志 
刘兆华 
摘 要:目的探讨 P 物质(substance P, SP)、降钙素基因相关肽(calcitonin gene-related peptide, CGRP)对内淋巴囊血流量及功能的影响, 为了解某些内耳疾病的病因提供实验基础和理论依据.方法建立 颈上神经节切除模型,通过计算机图象分析计算 SP、CGRP 量的变化,检测内淋巴囊血流量 .结果颈上神经节切除后 SP 明显减少(P<0.01),CGRP 无明显改变,内淋巴囊血流量明显减少(P<0.01).结论 SP、CGRP 等神经递质协同作用可 能通过调节内淋巴囊血流量进而影响内淋巴囊的功能.
关键词:内淋巴囊 颈上神经节 P物质 降钙素基因 相关肽 内淋巴囊血流量 豚鼠
文章编号:1006-7299(2002)04-0262-03
作者简介:窦艳玲(1970-),女,重庆人,医学硕士,主治医师,主要研究内耳病理及听力学
作者单位:窦艳玲(解放军452医院耳鼻咽喉科,成都,610021) 
     冯怀志(解放军452医院耳鼻咽喉科,成都,610021) 
     刘兆华(第三军医大学大坪医院耳鼻,咽喉-头颈外科) 
参考文献:
[1]Bradley P, Anderew R, Jiri Prazma, et al. Innervation of the endoly mphaic sac[J]. Arch Otolaryngol Head Neck Sur, 1992, 118:260.
[2]Hozawa K, Takasaka T. Sympathetic and CGRP-positive nerve supply t o the endolymphatic sac of guinea pig[J]. Acta Otolaryngol Suppl Stockh, 1993, 506:14.
[3]Birgersson L, Dfriberg U, Helge Rask-Anderson, et al. Adrenergic i nnervation of the human endolymphatic sac[J]. Acta Otolaryngol (stockh), 1994, 114:529.
[4]Angelborg C. Colored micropheres for blood flow determination twice in the same animal[J]. Hear Res, 1987, 27:265.
[5]汪吉宝,罗仁忠. 二色生物微球在耳蜗微循环实验中的作用[J]. 中华耳鼻咽喉科杂志,1993, 28:149.
[6]邱建华. 听觉及前庭径路上P物质[J]. 国外医学耳鼻咽喉科分册,1995, 15 :193.
[7]Birgersson L, Friberg U, Rask Andersen H, et al. Origin of sympathet ic and sensory innervation of the endolymphatic sac. A retrograde axonal tracing study in the guinea pig[J]. ORL J Otorhinolaryngol Relat Spec, 1992, 54:188.
[8]Dahlmann Annegret, Diiring Monika Von. The endolymphatic duct and sa c of the rat: a histogical, ultrastructural, and immunocytochemical investigatio n[J]. Cell Tissue Res, 1995, 282:277.
[9]Dagerlind A, Zhang X, Brimijoin S, et al. Eefects of preganglionic s ympathectomy on peptides in the superior cervical ganglion[J]. Neuroreport, 19 94, 5:909.
[10]Tomwall J,Konttinen YT,Usitalo H.Immunohistochemical distribution of calc itonin gene-related peptide in nerve fibres of the anterior buccal gland of th e rat[J].Histochem J,1996, 28:1.