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听力学及言语疾病杂志JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2002 Vol.10 No.1 P.34-37
正常清醒豚鼠的畸变产物耳声发射特性
Characteristics of Distortion Product Otoacoustic Emissions in Normal Awaked Guinea Pigs
罗燕云
黄治物
吴展元
肖伯奎
摘 要：目的研究正常清醒豚鼠的畸变产物耳声发射(DPOAE)的特性.方法采用CELESTA 503型耳声发射分析仪对26只正常清醒豚鼠(35耳)进行DP图及DP输入/输出曲线(DP-I/O)的测试,随机选择11只正常清醒豚鼠(20耳)进行DPOAE的重复测试,用SPSS 10.0对数据进行统计分析.结果在DP图中,当初始音强度L1/L2为70/65dB SPL时,正常清醒豚鼠的DPOAE幅值随测试频率f0从0 75～8 kHz的增加而逐渐升高(27.90±1.96～50.65±0.71).在DP-I/O中,当f0分别为4、6、8 kHz时,正常清醒豚鼠的DPOAE幅值随L1/L2从70/65以5dB一挡降至15/10dB SPL而呈线性下降(P＜0.01),在L1/L2为55/50或60/55dB SPL处出现饱和或低谷,同一I/O曲线上L1/L2分别从70/65及55/50 dB SPL递减至阈值的I/O斜率(分别记为KT及KL)均接近于1,且KL大于KT(P＜0.01).重复测试的DPOAE幅值差异小(＜1dB SPL)且无统计学意义(P＞0.05).结论正常清醒豚鼠DPOAE测试充分表现了其捡出率高、反应幅值大、反应稳定及频率特异性好的特点,可以多次长期反复进行,适用于监测耳蜗外毛细胞功能及耳蜗非线性机制,尤其是长期监测耳蜗慢性损伤过程的研究.
关键词：畸变产物耳声发射 豚鼠
文章编号：1006-7299(2002)01-0034-04
基金项目：国家自然科学基金资助项目(项目编号:30000190)
作者简介：罗燕云(1974-),女,湖北人,硕士研究生,主要从事听力学研究,现在广州军区武汉总医院耳鼻咽喉科,430070.黄治物,通讯作者.(E-mai1:huang086@public.wh.hb.cn)
作者单位：罗燕云（广州军区武汉总医院耳鼻咽喉科,430070）
黄治物（武汉大学人民医院耳鼻咽喉-头颈外科,武汉,430060）
吴展元（武汉大学人民医院耳鼻咽喉-头颈外科,武汉,430060）
肖伯奎（武汉大学人民医院耳鼻咽喉-头颈外科,武汉,430060）
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